Endometrial Rejuvenation

Endometrial Rejuvenation is the process to improve the quality of the Endometrium for successful implantation of the embryo by improving the endometrial thickness & blood supply which helps embryos for implantation giving them proper nutrition & hormones.

The innermost lining of the uterus is called the endometrium. The uterus changes its size every month throughout a woman’s fertile years. Constant regeneration is the most unique factor of the endometrium, the endometrium is mostly made up of mucosal tissue which has two layers, the stratum basalis which is attached to the smooth muscle called myometrium which forms an anchor for the endometrium and this layer remains relatively unchanged, However, the second layer the stratum functional is dynamic and changes in response to the monthly hormone flow that guides the menstrual cycle. It is the endometrium where the fertilized egg implants itself if the female conceives. A female’s body prepares the endometrium to host the embryo as a part of the period cycle each month. The endometrial thickness increases and decreases which is influenced by the hormones estrogen and progesterone and progenitor cell populations and inflammatory mediators. If any of these factors are disturbed, the result will be endometrial disorders with intrauterine scar formation, dysregulated proliferation, and heavy menstrual bleeding.

The cycles of endometrial growth are caused by the hormones estrogen and progesterone. They also cause for the shedding endometrium through menstruation if the woman does not get pregnant. The endometrium is thinnest during periods and normally measures between 2 to 4 millimeters in thickness, before ovulation the endometrium starts getting thicker and may measure between 5 to 7 mm, the endometrium grows thicker and can measure up to about 11 mm towards ovulation. The endometrial thickness is at its greatest and can measure 16 mm at the time of ovulation when the hormones trigger the release of an egg. The embryo will simply not be able to attach to the wall of the uterus if the endometrium is not thick enough.

Endometrial thickness plays an important role in pregnancy. An endometrium that is neither too thick nor too thin is linked to chances for a healthy, full-term pregnancy. A normal endometrium allows the embryo to implant successfully and gets the correct nutrition it needs. The endometrium gets thicker during the later phase of the pregnancy. The most common cause of infertility is poor endometrial thickness. Endometrial thickness constantly lower than 7mm can be caused by several conditions like

• Low levels of Estrogen hormone

• Trauma to the uterus (cesarean sections, repetitive curettage),

• Previous anti- tumoral treatments (radiotherapy, chemotherapy, surgery)

• Asherman’s syndrome-formation of adhesions inside the endometrial cavity(scar tissues) either after-D&C or because of pelvic infections.

• Chronic infections (Endometritis, Pelvic Inflammatory Disease)

The main factor for implantation and pregnancy is adequate endometrial thickness, the success rates of ART (Assisted Reproductive Technology)is adversely affected by the thin endometrium. There are a number of treatment modalities to improve the endometrial thickness and subsequent endometrial receptivity.

These approaches comprising hormonal management by estradiol, HCG(Human chorionic Gonadotrophin, GnRH(Gonadotropin-releasing hormone, vasoactive substances like aspirin, vitamin –E, nitroglycerin, intra-uterine infusion of a growth factor-like G-CSF( as Granulocyte Colony Stimulating Factor and the latest applications like Platelet-rich plasma(PRP), electrical stimulation and regenerative medicine.PRP can stimulate proliferation and regeneration with a large number of cytokines and growth factors. The efficacy of PRP found to be good in cases of repeated abortions and in cases where there is no improvement in the thickness of endometrium with estrogen or in cases of oocyte donation or Asherman’s syndrome.PRP is a safe procedure with minimal risks of transmission of infectious diseases and immunological reactions as it is made with autologous blood samples and promotes endometrial growth and improves the outcome of pregnancy during IVF

• Women who have experienced several IVF failures because of the uterine factor.

• Women with Asherman´s syndrome.

• Women diagnosed with infertility caused by uterine hypoplasia

Endometrial Rejuvenation Treatment is successful if:

• Endometrial Thickness above 9 mm with a good blood supply is made after treatment.

• Sub-endometrial blood supply up to Zone 4 (zone which is closest to the embryo).

Endometrial Rejuvenation Treatment an innovative and extremely effective treatment to resolve the problem of poor endometrial health helps successful embryo implantation. The pregnancy can be achieved through Natural Fertilization, if that doesn’t work IVF and IUI are done. A true alternative to surrogacy for women who suffer from infertility because of uterine factors is provided endometrial regeneration.

GarbhaGudi IVF Centre which is one of the best IVF centres in Bangalore offers PRP therapy for uterine lining Improvement, for women who are unable to conceive due to poor endometrial receptivity or have undergone repetitive IVF failures due to thin endometrial lining. If one has been trying to conceive for a long time and has exhausted all the natural methods available, one might begin to feel like that is the end of the road,platelet rich plasma therapy for endometrial rejuvenation at GarbhaGudi IVF centre is a ray of Hope.